High-Pressure Liquid Chromatography for Quantitation of Antimicrobial Agents

Several methods are currently available for quantitation of antimicrobial drugs in serum and body fluids, e.g., microbiological, radioenzymatic, and radioimmune assays. Recently, high-pressure liquid chromatography (HPLC) has been implemented for quantitation of a variety of drugs, including antimic...

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Bibliographic Details
Published in:Reviews of infectious diseases 1980-03, Vol.2 (2), p.169-181
Main Authors: Yoshikawa, Thomas T., Maitra, Shyamal K., Schotz, Michael C., Guze, Lucien B.
Format: Article
Language:English
Subjects:
Acetates
Anti-Bacterial Agents - blood
Antibiotics
Antimicrobials
Blood plasma
Chromatography
Chromatography, High Pressure Liquid - economics
Chromatography, High Pressure Liquid - instrumentation
Chromatography, High Pressure Liquid - methods
Costs and Cost Analysis
Extraction
Humans
Liquid chromatography
Liquids
Pumps
Review Articles
Steepest descent method
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Summary:Several methods are currently available for quantitation of antimicrobial drugs in serum and body fluids, e.g., microbiological, radioenzymatic, and radioimmune assays. Recently, high-pressure liquid chromatography (HPLC) has been implemented for quantitation of a variety of drugs, including antimicrobial drugs. The general principles of chromatography, particularly in reference to HPLC, are reviewed. The methods and procedures for extraction, separation, detection, and quantitation of antimicrobial drugs by HPLC are discussed. Current HPLC techniques for measuring antimicrobial drugs in biological fluids are also summarized.
ISSN:0162-0886