Blastomycoma of the cerebellum. An ultrastructural study

Biopsy tissue from a cerebellar blastomycoma in a 48-year-old man was studied by electron microscopy. The fine structure of the fungi recapitulated that of the yeast forms described in cultures and culture implants. Mycelial forms were not encountered. The yeasts displayed lamellated cell walls and...

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Published in:Acta neuropathologica 1980, Vol.50 (2), p.109-114
Main Authors: Mirra, S S, Trombley, I K, Miles, M L
Format: Article
Language:English
Subjects:
Biopsy
Blastomycosis - pathology
Cell Membrane - ultrastructure
Cerebellar Diseases - pathology
Cerebellum - pathology
Cerebellum - ultrastructure
Desmosomes - ultrastructure
Humans
Macrophages - ultrastructure
Male
Microscopy, Electron
Middle Aged
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container_title Acta neuropathologica
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creator Mirra, S S
Trombley, I K
Miles, M L
description Biopsy tissue from a cerebellar blastomycoma in a 48-year-old man was studied by electron microscopy. The fine structure of the fungi recapitulated that of the yeast forms described in cultures and culture implants. Mycelial forms were not encountered. The yeasts displayed lamellated cell walls and occasional multinucleation. Persistent broad-based budding with complex membranous profiles related to the cell membrane was prominent. The organisms were found within multinucleated giant cells and macrophages which exhibited subplasmalemmal linear densities and occasional desmosomal junctions.
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subjects Biopsy
Blastomycosis - pathology
Cell Membrane - ultrastructure
Cerebellar Diseases - pathology
Cerebellum - pathology
Cerebellum - ultrastructure
Desmosomes - ultrastructure
Humans
Macrophages - ultrastructure
Male
Microscopy, Electron
Middle Aged
title Blastomycoma of the cerebellum. An ultrastructural study
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