A Growth-Inhibitor for Streptomycin-resistant Mutants in Dense Suspensions of Brucella abortus (Strain 19)

IT was observed that when bacterial suspensions in broth were exposed to streptomycin in a concentration of 100 µgm. per ml. the survivors multiplied slowly after a prolonged lag phase 1 . It was also observed that, when bacterial suspensions containing 320–1,600 millions of Brucellæ per 10 ml. were...

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Bibliographic Details
Published in:Nature (London) 1953-01, Vol.171 (4342), p.132-133
Main Author: OLITZKI, A. L.
Format: Article
Language:English
Subjects:
Brucella abortus - drug effects
Growth Inhibitors
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
Streptomycin - pharmacology
Suspensions
Citations: Items that this one cites
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Summary:IT was observed that when bacterial suspensions in broth were exposed to streptomycin in a concentration of 100 µgm. per ml. the survivors multiplied slowly after a prolonged lag phase 1 . It was also observed that, when bacterial suspensions containing 320–1,600 millions of Brucellæ per 10 ml. were exposed to streptomycin, then the resistant mutants appeared in them more frequently than in those containing 1,600–8,000 millions of Brucellæ in the same volume 1 .
ISSN:0028-0836
1476-4687
DOI:10.1038/171132a0