Structure of Coenzyme A

CHEMICAL 1 and enzymic 2 studies from these two laboratories suggested that coenzyme A is best represented by formula (I) (cf. ref. 3). While the synthesis of various fragments of the molecule 4 has lent considerable support to this structure, the enzymic and chemical evidence did not agree on one p...

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Bibliographic Details
Published in:Nature (London) 1953-01, Vol.171 (4341), p.76-76
Main Authors: BADDILEY, J, THAIN, E. M, NOVELLI, G. D, LIPMANN, F
Format: Article
Language:English
Subjects:
Coenzyme A
Coenzymes
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
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Summary:CHEMICAL 1 and enzymic 2 studies from these two laboratories suggested that coenzyme A is best represented by formula (I) (cf. ref. 3). While the synthesis of various fragments of the molecule 4 has lent considerable support to this structure, the enzymic and chemical evidence did not agree on one point. This concerned the nature of a substance obtained by the action of nucleotide pyrophosphatase on the coenzyme and which stimulated the growth of Acetobacter suboxydans 5 . Although not isolated in a chemically pure state, it was thought to be a simple phosphate of pantothenic acid 6 . None of the synthetic pantothenic acid phosphates showed activity towards this organism ; consequently, it was suggested 1 that this ‘ Acetobacter -stimulatory factor’ might be pantetheine-4′phosphate (II). An unambiguous synthesis of (II) is described here.
ISSN:0028-0836
1476-4687
DOI:10.1038/171076a0