BICARBONATE AND CHLORIDE TRANSPORT IN RELATION TO THE ACIDIFICATION OR ALKALINIZATION OF THE URINE

Although the electrogenicity of the active reabsorption of sodium and bicarbonate (or secretion of protons) has been well-established in the short-circuited turtle bladder preparation, the nature of the active reabsorption of chloride and secretion of bicarbonate has been controversial. These proces...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1980-05, Vol.341 (1), p.210-224
Main Authors: Brodsky, William A., Durham, John H., Ehrenspeck, Gerhard
Format: Article
Language:English
Subjects:
Absorption
Acid-Base Equilibrium
Animals
Bicarbonates - metabolism
Biological Transport - drug effects
Chlorides - metabolism
Electrophysiology
Glucose - metabolism
Hydrogen-Ion Concentration
Models, Biological
Mucous Membrane - metabolism
Sodium - metabolism
Stilbenes - pharmacology
Turtles
Urinary Bladder - metabolism
Urine - metabolism
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Summary:Although the electrogenicity of the active reabsorption of sodium and bicarbonate (or secretion of protons) has been well-established in the short-circuited turtle bladder preparation, the nature of the active reabsorption of chloride and secretion of bicarbonate has been controversial. These processes have been ascribed to the separate actions of two discrete electrogenic pumps or to the single action of a metabolically driven electroneutral anion exchange mechanism. The present report deals with these transport processes per se; with the relations among serosal bicarbonate,glucose, and the reabsorption of Na and Cl; and finally with the application of the Heinz model for inversion of an active transport as a tentative single mechanism for the alkalinization and acidification of the urine.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1980.tb47173.x