Genetic linkage between Bf S0.7 (Bf S1) and HLA-Bw50

Two hundred and one unrelated French Basque individuals were studied for HLA-A, B, C, DR and Bf polymorphisms. The results show that the Bf S0.7 (Bf S1) variant, which is known to be associated with HLA-Bw21, presents a highly significant linkage disequilibrium with a subtypic specificity, i.e., Bw5...

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Bibliographic Details
Published in:Human genetics 1980-01, Vol.54 (3), p.417-418
Main Authors: Ohayon, E, de Mouzon, A, Hauptmann, G, Klein, J, Ducos, J
Format: Article
Language:English
Subjects:
Alleles
Complement Factor B - genetics
Enzyme Precursors - genetics
Ethnic Groups
France
Gene Frequency
Genetic Linkage
HLA Antigens - genetics
Humans
Phylogeny
Polymorphism, Genetic
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Summary:Two hundred and one unrelated French Basque individuals were studied for HLA-A, B, C, DR and Bf polymorphisms. The results show that the Bf S0.7 (Bf S1) variant, which is known to be associated with HLA-Bw21, presents a highly significant linkage disequilibrium with a subtypic specificity, i.e., Bw50 (delta = 0.0123, delta S=100%, P less than 10(-8)). As neither Bf S0.7 variant nor Bw50 antigen is found in Mongoloid populations, it is suggested that in evolutionary terms, the Bf S0.7 mutation is a more recent event than the HLA-Bw21 split.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00291591