The activity of metronidazole against facultatively anaerobic bacteria

This study demonstrates that various Gram-negative, facultatively anaerobic bacteria are capable of inactivating metronidazole, and contrary to previous reports, are sensitive to therapeutically attainable concentrations of this agent, when grown in pure culture under enhanced anaerobic conditions....

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1980-05, Vol.6 (3), p.343-347
Main Authors: Ingham, H. R., Hall, C. J., Sisson, Penelope R., Tharagonnet, Danka, Selkon, J. B.
Format: Article
Language:English
Subjects:
Anaerobiosis
Bacteria - drug effects
Bacteria - growth & development
Culture Media
Metronidazole - pharmacology
Microbial Sensitivity Tests
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study demonstrates that various Gram-negative, facultatively anaerobic bacteria are capable of inactivating metronidazole, and contrary to previous reports, are sensitive to therapeutically attainable concentrations of this agent, when grown in pure culture under enhanced anaerobic conditions. Metronidazole had no effect on strains of Staphylococcus aureus or Streptococcus faecalis grown under the same cultural conditions and these organisms did not inactivate the agent.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/6.3.343