Effect of Salt on the Vascular Lesions of Spontaneously Hypertensive Rats

SUMMARY High salt intake accelerates hypertension in humans and increases cardiovascular morbidity and mortality. The temporal relation between blood pressure (BP) deration and appearance of vascular lesions during salt-loading was studied in the spontaneously hypertensive rat (SHR). Starting at 5 w...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1980-07, Vol.2 (4), p.477-489
Main Authors: LIMAS, CATHERINE, WESTRUM, BARBARA, LIMAS, CONSTANTINOS J, COHN, JAY N
Format: Article
Language:English
Subjects:
Animals
Aorta - pathology
Hypertension - genetics
Hypertension - pathology
Kidney - blood supply
Male
Microscopy, Electron
Muscle, Smooth, Vascular - pathology
Muscle, Smooth, Vascular - ultrastructure
Rats
Sodium Chloride - pharmacology
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:SUMMARY High salt intake accelerates hypertension in humans and increases cardiovascular morbidity and mortality. The temporal relation between blood pressure (BP) deration and appearance of vascular lesions during salt-loading was studied in the spontaneously hypertensive rat (SHR). Starting at 5 weeks of age, SHRs and normotensive Wistar-Kyoto rats (WKYs) were given 1% NaCl in their drinking water; SHRs and WKYs on tap water served as controls. Animals from each group were sacrificed at 10 and 20 weeks of age, and the aorta and Intrarenal vessels were studied by light and electron microscopy.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.2.4.477