Synthesis and blood pressure lowering activity of 3-(substituted-amino)-1,2,4-benzothiadiazine 1-oxide derivatives

A series of (substituted amino)-1,2,4-benzothiadiazine 1-oxides has been synthesized and most members of the series have been shown to have blood pressure lowering effects in normotensive rabbits and in spontaneously hypertensive rats. The most active member of the series was 3-[4-(2-furoyl)-1-piper...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medicinal chemistry 1980-07, Vol.23 (7), p.717-722
Main Authors: Dillard, Robert D, Yen, Terence T, Stark, Paul, Pavey, Donald E
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - chemical synthesis
Benzothiadiazines - chemical synthesis
Benzothiadiazines - pharmacology
Hypertension - physiopathology
Male
Prazosin - pharmacology
Rabbits
Rats
Structure-Activity Relationship
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of (substituted amino)-1,2,4-benzothiadiazine 1-oxides has been synthesized and most members of the series have been shown to have blood pressure lowering effects in normotensive rabbits and in spontaneously hypertensive rats. The most active member of the series was 3-[4-(2-furoyl)-1-piperazinyl]-6,7-dimethoxy-1-methyl-1H-1,2,4-benzothiadiazine 1-oxide hydrochloride. This compound in animal tests was equipotent to the known antihypertensive Prazosin.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00181a003