Testosterone-Mediated Sexual Dimorphism of Mitochondria and Lysosomes in Mouse Kidney Proximal Tubules

In kidney proximal tubules of male mice the mitochondria are larger and more electron-lucent, autophagic vacuoles and lysosomes (predominantly myeloid bodies) more numerous and voluminous, and exocytosed intraluminal myeloid bodies more common than in females. Males also have higher kidney activitie...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1980-08, Vol.209 (4460), p.1023-1026
Main Authors: Koenig, Harold, Goldstone, Alfred, Blume, Gary, Lu, Chung Y.
Format: Article
Language:English
Subjects:
Animals
Castration
Cytochromes
Enzymes
Enzymes - urine
Excretion
Female
Kidney - drug effects
Kidney Tubules, Proximal - ultrastructure
Kidneys
Lysosomes
Lysosomes - drug effects
Lysosomes - enzymology
Male
Mice
Mitochondria
Mitochondria - drug effects
Mitochondria - enzymology
Orchiectomy
Organ Size - drug effects
Oxidases
Sex Differentiation - drug effects
Testosterone
Testosterone - pharmacology
Urine
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Summary:In kidney proximal tubules of male mice the mitochondria are larger and more electron-lucent, autophagic vacuoles and lysosomes (predominantly myeloid bodies) more numerous and voluminous, and exocytosed intraluminal myeloid bodies more common than in females. Males also have higher kidney activities of mitochondrial cytochrome c oxidase and lysosomal hydrolases, and excrete larger quantities of hydrolases and protein in the urine. Orchiectomy evokes the feminine pattern whereas testosterone administration induces the male pattern. Endogenous testosterone modulates mitochondrial structure and function and enhances the activity of the lysosomal-vacuolar system in proximal tubule cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7403864