Synthesis and biological evaluation of p-bromospiperone as potential neuroleptic drug

p-Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1980-08, Vol.69 (8), p.984-986
Main Authors: Huang, C.C., Friedman, A.M., So, R., Simonovic, M., Meltzer, H.Y.
Format: Article
Language:English
Subjects:
Animals
Antipsychotic Agents - chemical synthesis
Antipsychotic Agents - pharmacology
Binding, Competitive
Butyrophenones - chemical synthesis
Cattle
Caudate Nucleus - metabolism
Chemical Phenomena
Chemistry
In Vitro Techniques
Neuroleptics
Neuroleptics, potential—p-bromospiperone, synthesis and biological evaluation
Pituitary Gland, Anterior - metabolism
potential-p-bromospiperone
Prolactin - blood
Prolactin secretion-stimulation by p-bromospiperone
Receptors, Dopamine - drug effects
Spiperone - analogs & derivatives
Spiperone - chemical synthesis
Spiperone - metabolism
Spiperone - pharmacology
Spiperone-p-bromo analog
Spiperone—p-bromo analog, synthesis and biological evaluation as a potential neuroleptic
synthesis and biological evaluation
synthesis and biological evaluation as a potential neuroleptic
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Description
Summary:p-Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600690835