Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75

A DNA copy of the gene coding for the influenza A/Aichi/2/68 haemagglutinin protein was cloned in the plasmid pBR322 and the complete nucleotide sequence determined. Comparison of this primary structure and the deduced amino acid sequence with the haemagglutinin gene and protein of strains belonging...

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Bibliographic Details
Published in:Nature (London) 1980-08, Vol.286 (5775), p.771-776
Main Authors: Verhoeyen, Martine, Fang, Rongxiang, Jou, Willy Min, Devos, René, Huylebroeck, Danny, Saman, Eric, Fiers, Walter
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigens, Viral - genetics
Base Sequence
Cloning, Molecular - methods
Genes
Glycoproteins - genetics
Hemagglutinins, Viral - immunology
Humanities and Social Sciences
Influenza A virus - genetics
Influenza A virus - immunology
multidisciplinary
Mutation
Science
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Summary:A DNA copy of the gene coding for the influenza A/Aichi/2/68 haemagglutinin protein was cloned in the plasmid pBR322 and the complete nucleotide sequence determined. Comparison of this primary structure and the deduced amino acid sequence with the haemagglutinin gene and protein of strains belonging to the same (H3) subtype and to different subtypes, of both human (H2) and avian (Hav1) origin, documents further at the molecular level the two independent modes of antigenic variation of the virus—drift and shift.
ISSN:0028-0836
1476-4687
DOI:10.1038/286771a0