Cephalosporin N : a New Type of Penicillin

A SPECIES of Cephalosporium has been found to produce two different kinds of antibacterial substance 1,2 . The first consists of a group of acidic antibiotics which are soluble in common organic solvents, are active mainly against Gram-positive organisms 2 , and show similarities to helvolic acid 2–...

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Bibliographic Details
Published in:Nature (London) 1953-02, Vol.171 (4347), p.343-343
Main Authors: ABRAHAM, E. P, NEWTON, G. G. F, CRAWFORD, K, BURTON, H. S, HALE, C. W
Format: Article
Language:English
Subjects:
Humanities and Social Sciences
Humans
letter
multidisciplinary
Old Medline
Penicillins
Science
Science (multidisciplinary)
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Summary:A SPECIES of Cephalosporium has been found to produce two different kinds of antibacterial substance 1,2 . The first consists of a group of acidic antibiotics which are soluble in common organic solvents, are active mainly against Gram-positive organisms 2 , and show similarities to helvolic acid 2–4 . The second consists of a substance (or group of substances) which is insoluble in most organic solvents and is active against a number of Gram-positive and Gram-negative organisms. This has been called ‘cephalosporin N ’. Evidence has now been obtained that cephalosporin N is a new type of penicillin.
ISSN:0028-0836
1476-4687
DOI:10.1038/171343a0