Opioid Receptors Undergo Axonal Flow

Previous studies have indicated the presence of opiate receptors on axons of the rat vagus nerve and on other small diameter fibers. In examinations of the effect of ligation on the distribution of receptors in the vagus nerve by in vitro labeling light microscopic autoradiography, a large buildup o...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1980-10, Vol.210 (4465), p.76-78
Main Authors: Young, W. Scott, Wamsley, James K., Zarbin, Marco A., Kuhar, Michael J.
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Axonal Transport
Binding sites
Enkephalins - metabolism
Ganglia
Ligation
Nerves
Neurons
Nodose ganglion
Nodose Ganglion - physiology
Opiates
Opioid receptors
Rats
Receptors
Receptors, Opioid - metabolism
Receptors, Opioid - physiology
Vagus nerve
Vagus Nerve - physiology
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Summary:Previous studies have indicated the presence of opiate receptors on axons of the rat vagus nerve and on other small diameter fibers. In examinations of the effect of ligation on the distribution of receptors in the vagus nerve by in vitro labeling light microscopic autoradiography, a large buildup of receptors was found proximal to the ligature. This result indicates an axonal flow of receptors.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6158097