Circulating immune complexes in giant cell arteritis and polymyalgia rheumatica

Sera from 74 patients with polymyalgia rheumatica or giant cell arteritis or both were tested for immune complexes by using the Raji cell radioimmunoassay. Levels in patients with active disease were higher than in patients whose disease had become inactive. There was no difference in levels of immu...

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Bibliographic Details
Published in:Arthritis and rheumatism 1980-09, Vol.23 (9), p.1021-1025
Main Authors: Papaioannou, Christos C., Gupta, Ramesh C., Hunder, Gene G., Mcduffie, Frederic C.
Format: Article
Language:English
Subjects:
Aged
Antigen-Antibody Complex
Female
Giant Cell Arteritis - diagnosis
Giant Cell Arteritis - etiology
Giant Cell Arteritis - immunology
Humans
Male
Middle Aged
Polymyalgia Rheumatica - diagnosis
Polymyalgia Rheumatica - etiology
Polymyalgia Rheumatica - immunology
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Summary:Sera from 74 patients with polymyalgia rheumatica or giant cell arteritis or both were tested for immune complexes by using the Raji cell radioimmunoassay. Levels in patients with active disease were higher than in patients whose disease had become inactive. There was no difference in levels of immune complexlike materials between patients with polymyalgia rheumatica alone and those with giant cell arteritis. Density gradient analysis of one serum showed immune complex‐like materials mainly in the 19S region. Immune complexes may be important in the pathogenesis of these conditions.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780230909