Stimulation of gastric acid secretion and suppression of VIP-like immunoreactivity by bombesin in the Atlantic codfish, Gadus morhua [vasoactive intestinal polypeptide, radioimmunoassay]

Cods were equipped with cannulae for drainage of the stomach and for separate perfusion of the stomach (pure sea‐water) and intestine (diluted sea‐water). Acidity and volume of gastric effluence were measured. Plasma immunoreactive gastrin and vasoactive intestinal polypeptide (VIP) were assayed in...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1980-06, Vol.109 (2), p.217-223
Main Authors: HOLSTEIN, B., HUMPHREY, C. S.
Format: Article
Language:English
Subjects:
Animals
Body Weight
Bombesin
Bombesin - pharmacology
Female
fish physiology
Fishes - physiology
gastric acid secretion
Gastric Juice - secretion
gastrin
Gastrins - blood
Gastrointestinal Hormones - pharmacology
Male
Pentagastrin - pharmacology
Peptides - pharmacology
Radioimmunoassay
Vasoactive Intestinal Peptide - immunology
Vasoactive Intestinal Peptide - pharmacology
VIP
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Summary:Cods were equipped with cannulae for drainage of the stomach and for separate perfusion of the stomach (pure sea‐water) and intestine (diluted sea‐water). Acidity and volume of gastric effluence were measured. Plasma immunoreactive gastrin and vasoactive intestinal polypeptide (VIP) were assayed in some experiments. The high rate of “basal” acid secretion was further elevated by i.m. administration of bombesin, but not by pentagastrin. Exogenous VIP inhibited acid secretion. Following 5 h of bombesin infusion, plasma gastrin‐IR was unaffected while VIP‐IR was depressed compared to saline‐treated controls. The possibility that bombesin stimulates acid secretion by inhibiting VIP‐release is discussed.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1980.tb06589.x