Correlation of prognostic factors and blood lymphocyte subtypes in non‐Hodgkin's lymphoma

The total lymphocyte, T, B, and null cell content of peripheral blood from 32 healthy individuals and 30 patients with non‐Hodgkin's lymphoma was determined. The patients had a significant reduction of B cells (complement receptor and membrane immunoglobulin positive cells) and a significant re...

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Bibliographic Details
Published in:Cancer 1980-10, Vol.46 (8), p.1817-1824
Main Authors: Murray, J. Lee, Hurtubise, Paul E., Young, Donn C., Balcerzak, Stanley P., Lobuglio, Albert F.
Format: Article
Language:English
Subjects:
Agammaglobulinemia - diagnosis
B-Lymphocytes - immunology
Female
gamma-Globulins - analysis
Humans
Leukocyte Count
Lymphocytes - classification
Lymphoma - blood
Lymphoma - diagnosis
Lymphopenia - diagnosis
Male
Middle Aged
Prognosis
T-Lymphocytes - immunology
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Summary:The total lymphocyte, T, B, and null cell content of peripheral blood from 32 healthy individuals and 30 patients with non‐Hodgkin's lymphoma was determined. The patients had a significant reduction of B cells (complement receptor and membrane immunoglobulin positive cells) and a significant reduction in T cells. Correlation of patients' characteristics with lymphocyte abnormalities demonstrated several findings. Patients with advanced disease (III and IV) had significantly lower total lymphocyte and T cells than patients with localized disease (I and II) or normal controls. Patients with hypogammaglobulinemia had lower total lymphocyte and T cells than patients with normal gamma globulin status or normal controls. Patients with diffuse histology and B symptoms had lower total lymphocyte and T cells than normal controls. Discriminant analysis of lymphocyte populations categorized patients by disease extent and gamma globulin status with 70 and 68% accuracy, respectively.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19801015)46:8<1817::AID-CNCR2820460820>3.0.CO;2-C