Contrasting Effects of Activated and Nonactivated Macrophages and Macrophages From Tumor-Bearing Mice on Tumor Growth In Vivo

The effect of macrophages from normal and tumor-bearing mice on tumor growth was investigated with the use of an in vivo neutralization test. Macrophages from unstimulated and thioglycollate-stimulated peritoneal cavities (nonactivated macrophages) of normal mice enhanced growth of various syngeneic...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1980-11, Vol.65 (5), p.913-920
Main Authors: Gabizon, Alberto, Leibovich, S. Joseph, Goldman, Rachel
Format: Article
Language:English
Subjects:
Animals
Ascitic Fluid - cytology
Fibrosarcoma - immunology
Lymphoma - immunology
Macrophages - immunology
Melanoma - immunology
Mice
Mice, Inbred Strains
Neoplasm Transplantation
Neoplasms, Experimental - immunology
Neoplasms, Experimental - physiopathology
Propionibacterium acnes - immunology
Thioglycolates - immunology
Transplantation Immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of macrophages from normal and tumor-bearing mice on tumor growth was investigated with the use of an in vivo neutralization test. Macrophages from unstimulated and thioglycollate-stimulated peritoneal cavities (nonactivated macrophages) of normal mice enhanced growth of various syngeneic tumors [a 3-methylcholanthrene-induced transplantable fibrosarcoma from inbred C3HeB mice, a spontaneously originated transplantable melanoma (B16) from inbred C57BL/6 mice, and a radiation-induced lymphoma from inbred BALB/c mice]. This enhancing effect was not destroyed by irradiation of macrophages and was apparently mediated by macrophage secretory products. The effect appeared to be unrelated to immunosuppression and may have reflected direct stimulation of tumor cells. In contrast, Corynebacterium parvum-activated macrophages markedly inhibited tumor growth. Peritoneal macrophages from fibrosarcoma-bearing mice, which possessed tumor-inhibitory T-lymphocytes, enhanced tumor growth and abolished the effects of the tumor-inhibitory lymphocytes. Clearly, under certain conditions nonactivated macrophages interfered with the mechanisms of T-cell-mediated antitumor resistance in tumor-bearing mice.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/65.5.913