Surfactant for hyaline membrane disease

Since it has been demonstrated that hyaline membrane disease (HMD) is due to a relative deficiency of lung surfactant,1,2 one possible approach to the treatment or prevention of HMD in premature infants might be the introduction of surfactant into the lungs. Thus far, attempts at aerosolization of e...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1980-11, Vol.66 (5), p.795-798
Main Authors: Fujiwara, T, Adams, F H
Format: Article
Language:English
Subjects:
Animals
Ductus Arteriosus, Patent - complications
Humans
Hyaline Membrane Disease - complications
Hyaline Membrane Disease - prevention & control
Infant, Newborn
Rats
Sheep
Surface Tension
Surface-Active Agents - administration & dosage
Surface-Active Agents - chemical synthesis
Surface-Active Agents - therapeutic use
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Summary:Since it has been demonstrated that hyaline membrane disease (HMD) is due to a relative deficiency of lung surfactant,1,2 one possible approach to the treatment or prevention of HMD in premature infants might be the introduction of surfactant into the lungs. Thus far, attempts at aerosolization of either synthetic surfactant (dipalmitoyl lecithin [DPL]) or natural surfactant into the lungs of patients or animals have failed to produce convincing benefits.3-5 On the other hand, direct instillation of a solution of natural surfactant into the trachea seems to produce striking results. Enhòˆrning et al6 were the first to show that tracheal deposition of natural surfactant into premature rabbit fetuses before the first breath enhanced air intake and improved the pressure-volume relationships of the lungs; it also increased their survival time.7
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.66.5.795