Effect of inactivator(s) formed from copper and phenol impurity(ies) on the sedimentation rate of transfective poliovirion RNA

Transfective poliovirion RNA after inactivation by the inactivator or inactivators formed from copper and an impurity or impurities in reagent-grade phenol sediments more heterogeneously and, on the average, more slowly than intact transfective RNA. The data are consistent with the hypothesis that t...

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Bibliographic Details
Published in:Archives of virology 1980-01, Vol.66 (1), p.45-51
Main Authors: Dubes, G R, Al-Moslih, M I
Format: Article
Language:English
Subjects:
Centrifugation, Density Gradient
Copper - pharmacology
Phenols - pharmacology
Poliovirus - metabolism
RNA, Viral - analysis
RNA, Viral - isolation & purification
RNA, Viral - metabolism
Transfection - drug effects
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Summary:Transfective poliovirion RNA after inactivation by the inactivator or inactivators formed from copper and an impurity or impurities in reagent-grade phenol sediments more heterogeneously and, on the average, more slowly than intact transfective RNA. The data are consistent with the hypothesis that the inactivator causes scission of the viral RNA molecules.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01315043