I.V. MIDAZOLAM AS AN INDUCTION AGENT FOR ANAESTHESIA: A STUDY IN VOLUNTEERS

The central nervous and cardiovascular effects of midazolam 0.15 mg kg−1 were studied in 20 healthy, unpremedicated volunteers (10 male and 10 female). No important side-effects were noted and the venous tolerance to midazolam was excellent. Three minutes after injection mean systolic arterial press...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1980-09, Vol.52 (9), p.907-911
Main Authors: FORSTER, A., GARDAZ, J.-P., SUTER, P.M., GEMPERLE, M.E.
Format: Article
Language:English
Subjects:
Adult
Anesthesia, Intravenous - methods
Anti-Anxiety Agents - pharmacology
Benzodiazepines - pharmacology
Brain - drug effects
Female
Hemodynamics - drug effects
Humans
Male
Midazolam
Sex Factors
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Summary:The central nervous and cardiovascular effects of midazolam 0.15 mg kg−1 were studied in 20 healthy, unpremedicated volunteers (10 male and 10 female). No important side-effects were noted and the venous tolerance to midazolam was excellent. Three minutes after injection mean systolic arterial pressure decreased from 121±(SEM) 2 mm Hg to 115±(SEM) 2 mm Hg and diastolic pressure from 78±2 to 70±2 mm Hg (P
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/52.9.907