Simian Virus 40-Associated Fatal Interstitial Pneumonia and Renal Tubular Necrosis in a Rhesus Monkey

Simian virus 40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and the kidney. These inclusions were pos...

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Bibliographic Details
Published in:The Journal of infectious diseases 1980-10, Vol.142 (4), p.618-622
Main Authors: Sheffield, W. Douglas, Strandberg, John D., Braun, Lundy, Shah, Keerti, Kalter, S. S.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - etiology
Animals
Antiserum
Epithelial cells
Experimental Medicine
Immunoenzyme Techniques
Infections
Kidney Tubular Necrosis, Acute - etiology
Kidney Tubular Necrosis, Acute - pathology
Kidneys
Lesions
Lung - ultrastructure
Lungs
Lymph Nodes - pathology
Macaca mulatta
Male
Pneumocytes
Pneumonia, Pneumocystis - etiology
Pneumonia, Pneumocystis - pathology
Rabbits
Simian virus 40
Simian virus 40 - isolation & purification
Spleen - pathology
Thymus Gland - pathology
Viral pneumonia
Viruses
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Description
Summary:Simian virus 40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and the kidney. These inclusions were positive for antigen of simian virus 40 by immunoperoxidase staining of paraffin sections of affected organs. Electron microscopy revealed characteristic papovavirus particles in these tissues. This study is the first report indicating that simian virus 40 may produce pulmonary and renal disease in its natural host.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/142.4.618