Enzymic Content of the Mitochondria Fraction

A LARGE number of enzymes have been located in the mitochondria fraction isolated by means of differential centrifugation; this fact is generally assumed to indicate that they are structurally associated within the living cell. Recent studies, part of which were presented at the second International...

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Bibliographic Details
Published in:Nature (London) 1953-12, Vol.172 (4390), p.1143-1144
Main Authors: DUVE, C. DE, GIANETTO, R., APPELMANS, F., WATTIAUX, R.
Format: Article
Language:English
Subjects:
Enzymes
Humanities and Social Sciences
letter
Mitochondria
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
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Summary:A LARGE number of enzymes have been located in the mitochondria fraction isolated by means of differential centrifugation; this fact is generally assumed to indicate that they are structurally associated within the living cell. Recent studies, part of which were presented at the second International Congress of Biochemistry 1 , have shown that this conclusion is not necessarily warranted. It has been found that the acid phosphatase of rat liver, which comes down predominantly with the large granules in a form which, in the native particles, is practically devoid of activity towards added glycerophosphate at p H 5 2–4 , does not belong to the same type of granules as cytochrome oxidase.
ISSN:0028-0836
1476-4687
DOI:10.1038/1721143a0