Virulence of Escherichia coli in acute pyelonephritis, acute cystitis and asymptomatic bacteriuria

E. coli strains were isolated from urine specimens of hospitalised patients with acute pyelonephritis, acute cystitis or asymptomatic bacteriuria (ABU), and tested for virulence in an experimental mouse model. Of 12 pyelonephritis-strains 11 were shown to be virulent and 1 avirulent; of 12 cystitis-...

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Bibliographic Details
Published in:Antonie van Leeuwenhoek 1980-01, Vol.46 (4), p.321-329
Main Authors: van den Bosch, J F, Oe, P L, Postma, P, de Graaff, J, MacLaren, D M, Jansen, W H, Guinée, P A
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Bacteriuria - microbiology
Cystitis - microbiology
Escherichia coli - classification
Escherichia coli - pathogenicity
Escherichia coli Infections - microbiology
Humans
Mice
Pyelonephritis - microbiology
Serotyping
Urine - microbiology
Virulence
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Summary:E. coli strains were isolated from urine specimens of hospitalised patients with acute pyelonephritis, acute cystitis or asymptomatic bacteriuria (ABU), and tested for virulence in an experimental mouse model. Of 12 pyelonephritis-strains 11 were shown to be virulent and 1 avirulent; of 12 cystitis-strains 4 were virulent and 8 avirulent; of 12 ABU-strains 5 were virulent and 7 avirulent. It is concluded that, while no difference in virulence was found between cystitis- and ABU-strains, pyelonephritis-strains were more often virulent than cystitis- and ABU-strains. No associations could be shown between virulence of the isolated strains and the presence of antibody-coated bacteria in the urine. Common urinary O types were not more often virulent than other O types. No relationship was seen between virulence and the presence of K antigen or the presence of particular K types.
ISSN:0003-6072
1572-9699
DOI:10.1007/BF00421979