Elevated serum parathyroid hormone concentration during treatment with high ceiling diuretics

Serum concentrations of parathyroid hormone (s-PTH) calcium, phosphorus and alkaline phosphatase were measured during treatment with furosemide or bumetanide for congestive heart failure. Significant elevations both of s-PTH and alkaline phosphatase were found, whereas serum calcium concentration wa...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1980-10, Vol.18 (4), p.363-364
Main Authors: Elmgreen, J, Tougaard, L, Leth, A, Christensen, M S
Format: Article
Language:English
Subjects:
Adult
Aged
Bumetanide - pharmacology
Calcium - blood
Diuretics - pharmacology
Furosemide - pharmacology
Humans
Middle Aged
Parathyroid Hormone - blood
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Summary:Serum concentrations of parathyroid hormone (s-PTH) calcium, phosphorus and alkaline phosphatase were measured during treatment with furosemide or bumetanide for congestive heart failure. Significant elevations both of s-PTH and alkaline phosphatase were found, whereas serum calcium concentration was decreased. The changes were not related to the dose of drug or to the duration of treatment. It is concluded that treatment with furosemide or bumetanide may cause hypocalcaemia, resulting in elevation of s-PTH. The increased concentration of alkaline phosphatase may indicate accelerated bone remodelling, as found in primary hyperparathyroidism.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00561397