Sensory-induced activation of pattern generators in the absence of supraspinal control

Sacrocaudal afferent (SCA) stimulation is used in this work to study neural pathways involved in sensory‐activation of central pattern generators (CPGs) in the isolated spinal cord of the neonatal rat. Surgical manipulations of the white matter funiculi and confocal imaging of back‐labeled funicular...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2010-06, Vol.1198 (1), p.54-62
Main Authors: Lev-Tov, A., Etlin, A., Blivis, D.
Format: Article
Language:English
Subjects:
Activation
Afferent Pathways - physiology
Animals
Animals, Newborn
ascending pathways
Axons - physiology
Cats
Confocal
Dendrites - physiology
Electric Stimulation
Functional Laterality
Generators
Hindlimb - innervation
Levodopa - pharmacology
locomotor
Mice
Neurons
Neurons - physiology
Pathways
Physical Stimulation
propriospinal
Rats
Rhythm
sacrocaudal afferents
Spinal cord
Spinal Cord - physiology
spinal motoneurons
Spinal Nerve Roots - physiology
Stimulation
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Summary:Sacrocaudal afferent (SCA) stimulation is used in this work to study neural pathways involved in sensory‐activation of central pattern generators (CPGs) in the isolated spinal cord of the neonatal rat. Surgical manipulations of the white matter funiculi and confocal imaging of back‐labeled funicular pathways suggest that the CPGs are activated during SCA stimulation by crossed and uncrossed multifunicular projections of sacral neurons and that activation of short projecting proprioneurons is sufficient for the generation of the rhythm by SCA stimulation. The versatile organization of the pathways involved in the SCA‐induced rhythm makes it a potent and durable activator of the CPGs in the absence of descending control from the brain. The significance of our findings and their potential clinical use are discussed.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2009.05424.x