Monitoring of cell cultures with LTCC microelectrode array

Monitoring of cell cultures in microbioreactors is a crucial task in cell bioassays and toxicological tests. In this work a novel tool based on a miniaturized sensor array fabricated using low-temperature cofired ceramics (LTCC) technology is presented. The developed device is applied to the monitor...

Full description

Saved in:
Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2009-04, Vol.393 (8), p.2029-2038
Main Authors: Ciosek, P, Zawadzki, K, Łopacińska, J, Skolimowski, M, Bembnowicz, P, Golonka, L. J, Brzózka, Z, Wróblewski, W
Format: Article
Language:English
Subjects:
Analytical Chemistry
Animals
Applied sciences
Arrays
Biochemistry
Bioreactors
Cell Culture Techniques - methods
Ceramics
Cercopithecus aethiops
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Cold Temperature
Culture
Culture Media - analysis
Culture Media - chemistry
cultured cells
Electrochemical methods
Exact sciences and technology
Food Science
Global environmental pollution
Humans
Ion-selective electrodes
Laboratory Medicine
LTCC
Mathematical analysis
Microelectrodes
Microfluidic Analytical Techniques - methods
Microorganisms
Microtechnology - methods
Miniaturization
Monitoring
Monitoring/Environmental Analysis
Original Paper
Pollution
Sensor array
Tasks
Toxicology
Tumor Cells, Cultured
Vero Cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Monitoring of cell cultures in microbioreactors is a crucial task in cell bioassays and toxicological tests. In this work a novel tool based on a miniaturized sensor array fabricated using low-temperature cofired ceramics (LTCC) technology is presented. The developed device is applied to the monitoring of cell-culture media change, detection of the growth of various species, and in toxicological studies performed with the use of cells. Noninvasive monitoring performed with the LTCC microelectrode array can be applied for future cell-engineering purposes. [graphic removed]
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-009-2651-x