Redox cycling in nanofluidic channels using interdigitated electrodes

Amperometric detection is ideally suited for integration into micro- and nanofluidic systems as it directly yields an electrical signal and does not necessitate optical components. However, the range of systems to which it can be applied is constrained by the limited sensitivity and specificity of t...

Full description

Saved in:
Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2009-05, Vol.394 (2), p.447-456
Main Authors: Goluch, Edgar D, Wolfrum, Bernhard, Singh, Pradyumna S, Zevenbergen, Marcel A. G, Lemay, Serge G
Format: Article
Language:English
Subjects:
Amperometric detection
Amplification
Analytical Chemistry
ascorbic acid
Biochemistry
Channels
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Cycles
Electrical measurements
electrochemistry
Electrodes
Food Science
Interdigitated electrodes (IDEs)
Laboratory Medicine
Monitoring/Environmental Analysis
Nanocomposites
Nanofluidic
Nanofluids
Nanomaterials
Nanostructure
nanotechnology
Original Paper
Paracetamol
Redox cycling
Sensor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amperometric detection is ideally suited for integration into micro- and nanofluidic systems as it directly yields an electrical signal and does not necessitate optical components. However, the range of systems to which it can be applied is constrained by the limited sensitivity and specificity of the method. These limitations can be partially alleviated through the use of redox cycling, in which multiple electrodes are employed to repeatedly reduce and oxidize analyte molecules and thereby amplify the detected signal. We have developed an interdigitated electrode device that is encased in a nanofluidic channel to provide a hundred-fold amplification of the amperometric signal from paracetamol. Due to the nanochannel design, the sensor is resistant to interference from molecules undergoing irreversible redox reactions. We demonstrate this selectivity by detecting paracetamol in the presence of excess ascorbic acid. [graphic removed]
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-008-2575-x