Macrocyclic antibiotics as chiral selectors in the design of enantioselective, potentiometric membrane electrodes for the determination of S-flurbiprofen

Construction of three novel enantioselective, potentiometric membrane electrodes based on carbon paste impregnated with different macrocyclic antibiotics vancomycin and teicoplanin as chiral selectors are described. The solutions for the construction of electrodes were prepared in phosphate buffer p...

Full description

Saved in:
Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2009-06, Vol.394 (3), p.821-826
Main Authors: Stefan-van Staden, Raluca-Ioana, van Staden, Jacobus F, Aboul-Enein, Hassan Y
Format: Article
Language:English
Subjects:
Analytical Chemistry
Antibiotics
Biochemistry
Carbon
Carbon - chemistry
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Construction
Electrochemical methods
Electrodes
Exact sciences and technology
Flurbiprofen - analysis
Food Science
Hydrogen-Ion Concentration
Laboratory Medicine
Macrocyclic compounds
Macrocyclic Compounds - chemistry
Membranes
Membranes, Artificial
Molecular Structure
Monitoring/Environmental Analysis
Original Paper
Potentiometry - methods
Selectors
Stereoisomerism
TCP (protocol)
Teicoplanin - chemistry
Vancomycin - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Construction of three novel enantioselective, potentiometric membrane electrodes based on carbon paste impregnated with different macrocyclic antibiotics vancomycin and teicoplanin as chiral selectors are described. The solutions for the construction of electrodes were prepared in phosphate buffer pH 4 for the vancomycin-based electrode (VCM), pH 6 and pH 6/40% acetonitrile solutions for teicoplanin-based electrodes, TCP I and II, respectively. The proposed electrodes were applied in the assay of S-flurbiprofen raw material and its pharmaceutical formulation by use of direct potentiometry, VCM electrode exhibiting the best enantioselectivity. The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-009-2742-8