Critical aspects of biointerface design and their impact on biosensor development

The stable integration of a biological recognition element on a transducing substrate surface is the single most important step in the creation of a high-functioning sensor surface. The key factors affecting biotic and abiotic functionalities at the biointerface are both chemical and physical. Under...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2010-06, Vol.397 (3), p.925-933
Main Authors: North, Stella H, Lock, Evgeniya H, Taitt, Chris R, Walton, Scott G
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Bio-immobilization
Biochemistry
Biointerface
Biological and medical sciences
Biomolecules
Biosensing Techniques - methods
Biosensing Techniques - trends
Biosensor
Biosensors
Biotechnology
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Computer interfaces
Design and construction
Dielectric films
Exact sciences and technology
Food Science
Fundamental and applied biological sciences. Psychology
General, instrumentation
Laboratory Medicine
Materials
Mathematical analysis
Methods. Procedures. Technologies
Monitoring/Environmental Analysis
Physiological aspects
Product development
Properties
Surface characterization
Surface functionalization
Surface Properties
Surface topography
Thin films
Topographical drawing
Trends
Various methods and equipments
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Summary:The stable integration of a biological recognition element on a transducing substrate surface is the single most important step in the creation of a high-functioning sensor surface. The key factors affecting biotic and abiotic functionalities at the biointerface are both chemical and physical. Understanding the interactions between biomolecules and surfaces, and their emergent complexity, is critical for biointerface implementation for sensing applications. In this overview, we highlight materials and methods typically used for biosensor development. Particular emphasis has been given to the experimental evaluation of biointerfacial properties and functionality. Promising research directions for application of biointerfaces to biosensing are suggested. [graphic removed]
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-010-3637-4