Non-Conventional Applications of Computerized Tomography: Analysis of Solid Dosage Forms Produced by Pharmaceutical Industry

X-ray computed tomography (CT) refers to the cross-sectional imaging of an object measuring the transmitted radiation at different directions. In this work, we describe a non-conventional application of computerized tomography: visualization and improvements in the understanding of some internal str...

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Bibliographic Details
Published in:Proceedings of the 32nd Workshop 2009-09, Vol.1245, p.153-159
Main Authors: De Oliveira Jr, Jose Martins, Germano Martins, Antonio Cesar
Format: Article
Language:English
Subjects:
Computation
Cross sections
Density distribution
Dosage
Granular materials
Granules
Imaging
Pharmaceuticals
Porosity
Scanners
Tablets
Tomography
Visualization
X-rays
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Summary:X-ray computed tomography (CT) refers to the cross-sectional imaging of an object measuring the transmitted radiation at different directions. In this work, we describe a non-conventional application of computerized tomography: visualization and improvements in the understanding of some internal structural features of solid dosage forms. A micro-CT X-ray scanner, with a minimum resolution of 30 um was used to characterize some pharmaceutical tablets, granules, controlled-release osmotic tablet and liquid-filled soft-gelatin capsules. The analysis presented in this work are essentially qualitative, but quantitative parameters, such as porosity, density distribution, tablets dimensions, etc. could also be obtained using the related CT techniques.
ISSN:0094-243X