Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron

The major ligands of nontransferrin‐bound iron (NTBI) are suggested to be citrate and albumin. The proportion of iron binding to albumin is influenced by the degree of oxidation and glycation of the protein. LC‐ICP‐MS is demonstrated to be a useful technique for the speciation of NTBI, with unproces...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2010-08, Vol.1202 (1), p.94-99
Main Authors: Hider, R.C., Silva, A.M.N., Podinovskaia, M., Ma, Yongmin
Format: Article
Language:English
Subjects:
Albumins
Chelation
Chelation Therapy
Citrates
Citric Acid - chemistry
Citric Acid - metabolism
Efficiency
Ferritin
Fluorescent Dyes - chemistry
Fluorescent Dyes - metabolism
fluorescent reagent
Humans
Iron
Iron - chemistry
Iron - metabolism
Iron Chelating Agents - therapeutic use
Ligands
Molecular Structure
Monitoring
nontransferrin-bound iron
Speciation
Transferrin - metabolism
Treatment Outcome
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Summary:The major ligands of nontransferrin‐bound iron (NTBI) are suggested to be citrate and albumin. The proportion of iron binding to albumin is influenced by the degree of oxidation and glycation of the protein. LC‐ICP‐MS is demonstrated to be a useful technique for the speciation of NTBI, with unprocessed serum being subjected to analysis. Ferritin iron, citrate iron, and ferrioxamine can be quantified using this technique. This review describes the use of a new fluorescent probe for NTBI quantification.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2010.05573.x