Compatibility study between chlorpropamide and excipients in their physical mixtures

Chlorpropamide ((4-chloro- N -(propylamino)-carbonyl)-benzenesulfonamide) belongs to compounds having sulfonylurea group and is widely used as an oral antidiabetic agent. In this work differential scanning calorimetry (DSC) was used during pre-formulation of chlorpropamide tablets to determine the d...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2009-07, Vol.97 (1), p.355-357
Main Authors: Freire, Fátima Duarte, Aragão, C. Flávio Soares, de Lima e Moura, T. Flávio Accioly, Raffin, Fernanda Nervo
Format: Article
Language:English
Subjects:
Analytical Chemistry
Binary mixtures
Biological and medical sciences
Chemistry
Chemistry and Materials Science
Differential scanning calorimetry
Endothermic reactions
Excipients
General pharmacology
Inorganic Chemistry
Magnesium stearate
Measurement Science and Instrumentation
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physical Chemistry
Polymer Sciences
Sodium
Sulfates
Tablets
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Summary:Chlorpropamide ((4-chloro- N -(propylamino)-carbonyl)-benzenesulfonamide) belongs to compounds having sulfonylurea group and is widely used as an oral antidiabetic agent. In this work differential scanning calorimetry (DSC) was used during pre-formulation of chlorpropamide tablets to determine the drug-excipients compatibility. The DSC curves of chlorpropamide and binary mixtures with excipients (sodium croscarmellose, sodium lauryl sulfate, microcrystalline cellulose, magnesium stearate and calcium carbonate) showed that chlorpropamide exhibited interaction with magnesium stearate and sodium lauryl sulfate. The binary mixtures of chlorpropamide–magnesium stearate presented a single endothermic process at 96–108 °C and chlorpropamide–sodium lauryl sulfate showed a wide endotherm at 99–120 °C.
ISSN:1388-6150
1588-2926
1572-8943
DOI:10.1007/s10973-009-0258-2