Simultaneous Determination of Ibuprofen and Pseudoephedrine Hydrochloride in Pharmaceutical Tablets by Reversed-Phase HPLC

An isocratic HPLC method was developed and validated for the simultaneous determination of ibuprofen (IBU) and pseudoephedrine hydrochloride (PSE). Chromatography was carried out on an Apex phenyl column using 0.025 M acetic acid, triethylamine solution (pH 4.5) - acetonitrile (80:20, v/v) as mobile...

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Bibliographic Details
Published in:Analytical letters 2009-11, Vol.42 (18), p.2951-2961
Main Authors: Langlois, Marie-Hélène, Dallet, Philippe, Kauss, Tina, Dubost, Jean-Pierre
Format: Article
Language:English
Subjects:
Acetic acid
Acetonitrile
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
HPLC
Hydrochlorides
Ibuprofen
Mathematical analysis
Other chromatographic methods
pharmaceutical tablets
Pharmaceuticals
pseudoephedrine hydrochloride
Tablets
validation
Wavelengths
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Summary:An isocratic HPLC method was developed and validated for the simultaneous determination of ibuprofen (IBU) and pseudoephedrine hydrochloride (PSE). Chromatography was carried out on an Apex phenyl column using 0.025 M acetic acid, triethylamine solution (pH 4.5) - acetonitrile (80:20, v/v) as mobile phase at a flow rate of 1 mL · min −1 . UV detection was performed at a wavelength of 210 nm. The method was validated for specificity, linearity, accuracy, precision, and was successfully applied to pharmaceutical tablets of Rhinadvil®.
ISSN:0003-2719
1532-236X
DOI:10.1080/00032710903202006