Is there a role for thyroid hormone on spermatogenesis?

Appropriate level of thyroid hormone is essential for normal development and metabolism in most vertebrate tissues and altered thyroid status impacts adversely on them. For many years the testis was regarded as a thyroid hormone unresponsive organ, but consistent evidence accumulated in the past two...

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Bibliographic Details
Published in:Microscopy research and technique 2009-11, Vol.72 (11), p.796-808
Main Authors: Wagner, Marcia Santos, Wajner, Simone Magagnin, Maia, Ana Luiza
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Animals
Child
Child, Preschool
Control
Hormones
Humans
Infant
Infant, Newborn
iodothyronine deiodinases
Male
Models, Biological
Organs
Rats
Spermatogenesis
Spermatogenesis - physiology
Survival
Testes
testis
Testis - growth & development
Testis - physiology
thyroid hormone
Thyroid Hormones - physiology
Vertebrates
Young Adult
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Summary:Appropriate level of thyroid hormone is essential for normal development and metabolism in most vertebrate tissues and altered thyroid status impacts adversely on them. For many years the testis was regarded as a thyroid hormone unresponsive organ, but consistent evidence accumulated in the past two decades has definitively changed this classical view. Currently, the concept that thyroid hormone plays a critical role in testis development, in rats and other vertebrate species, is clearly established. Although the effects of thyroid hormone on Sertoli and Leydig cells in the immature testis are well described, its role on the adult organ remains controversial. In this review, we summarize and discuss the recent development on the thyroid hormone effects in immature and adult testes. Particularly, we have attempted to address the role of thyroid hormone in the regulation of spermatogenesis, emphasizing recent data that suggest its involvement in germ cells differentiation and survival. Microsc. Res. Tech. 2009. © 2009 Wiley‐Liss, Inc.
ISSN:1059-910X
1097-0029
DOI:10.1002/jemt.20759