Study of the spatial distribution of the absorbed dose in blood volumes irradiated using a teletherapy unit

• Published in: Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2010-06, Vol.79 (6), p.673-677
• Main Authors: Góes, E.G., Nicolucci, P., Nali, I.C., Pelá, C.A., Bruço, J.L., Borges, J.C., Covas, D.T.
• Format: Article
• Language: English
• Subjects: Bags; Blood; Blood irradiation; Blood volume; Devices; Homogeneity; Irradiation; Linear accelerators; Mathematical analysis; Quality control; TA-GVHD; Teletherapy
• ISSN: 0969-806X; 1879-0895
• DOI: 10.1016/j.radphyschem.2010.01.015

Blood irradiation can be performed using a dedicated blood irradiator or a teletherapy unit. A thermal device providing appropriate storage conditions during blood components irradiation with a teletherapy unit has been recently proposed. However, the most appropriated volume of the thermal device was not indicated. The goal of this study was to indicate the most appropriated blood volume for irradiation using a teletherapy unit in order to minimize both the dose heterogeneity in the volume and the blood irradiation time using these equipments. Theoretical and experimental methods were used to study the dose distribution in the blood volume irradiated using a linear accelerator and a cobalt-60 therapy machine. The calculation of absorbed doses in the middle plane of cylindrical acrylic volumes was accomplished by a treatment planning system. Experimentally, we also used cylindrical acrylic phantoms and thermoluminescent dosimeters to confirm the calculated doses. The data obtained were represented by isodose curves. We observed that an irradiation volume should have a height of 28 cm and a diameter of 28 cm and a height of 35 cm and a diameter of 35 cm, when the irradiation is to be performed by a linear accelerator and a cobalt-60 teletherapy unit, respectively. Calculated values of relative doses varied from 93% to 100% in the smaller volume, and from 66% to 100% in the largest one. A difference of 5.0%, approximately, was observed between calculated and experimental data. The size of these volumes permits the irradiation of blood bags in only one bath without compromising the homogeneity of the absorbed dose over the irradiated volume. Thus, these irradiation volumes can be recommend to minimize the irradiation time when a teletherapy unit is used to irradiate blood.