An efficient one-pot synthesis of 3-aryl-1,2,4-oxadiazol-5-amines under solvent-free conditions

The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with carbodiimides in the presence of molecular sieves under solvent-free conditions to produce the title compounds in excellent yields.

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Bibliographic Details
Published in:Mendeleev communications 2010-01, Vol.20 (1), p.50-51
Main Authors: Adib, Mehdi, Bagherzadeh, Sharareh, Mahdavi, Mohammad, Bijanzadeh, Hamid R.
Format: Article
Language:English
Subjects:
Carbodiimides
Condensing
Molecular sieves
Nitriles
Synthesis
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Description
Summary:The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with carbodiimides in the presence of molecular sieves under solvent-free conditions to produce the title compounds in excellent yields.
ISSN:0959-9436
DOI:10.1016/j.mencom.2010.01.019