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An efficient one-pot synthesis of 3-aryl-1,2,4-oxadiazol-5-amines under solvent-free conditions

The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with carbodiimides in the presence of molecular sieves under solvent-free conditions to produce the title compounds in excellent yields.

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Published in:Mendeleev communications 2010-01, Vol.20 (1), p.50-51
Main Authors: Adib, Mehdi, Bagherzadeh, Sharareh, Mahdavi, Mohammad, Bijanzadeh, Hamid R.
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Language:English
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container_title Mendeleev communications
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creator Adib, Mehdi
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description The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with carbodiimides in the presence of molecular sieves under solvent-free conditions to produce the title compounds in excellent yields.
doi_str_mv 10.1016/j.mencom.2010.01.019
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source ScienceDirect Freedom Collection 2022-2024
subjects Carbodiimides
Condensing
Molecular sieves
Nitriles
Synthesis
title An efficient one-pot synthesis of 3-aryl-1,2,4-oxadiazol-5-amines under solvent-free conditions
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