Measurement of the elasticity modulus of soft tissues

Abstract A measurement setup combined with a Finite Element (FE) simulation is presented to determine the elasticity modulus of soft materials as a function of frequency. The longterm goal of this work is to measure in vitro the elasticity modulus of human vocal folds over a frequency range that coi...

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Bibliographic Details
Published in:Journal of biomechanics 2010-05, Vol.43 (8), p.1540-1545
Main Authors: Zörner, S, Kaltenbacher, M, Lerch, R, Sutor, A, Döllinger, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomechanics. Biorheology
Computer Simulation
Elastic Modulus - physiology
Elasticity
Elasticity modulus
Equipment Design
Equipment Failure Analysis
Finite-element simulation
Frequency ranges
Fundamental and applied biological sciences. Psychology
Hardness Tests - instrumentation
Hardness Tests - methods
Human
Humans
Lasers
Material parameter simulation
Mathematical analysis
Mathematical models
Models, Biological
Partial differential equations
Phonation
Physical Medicine and Rehabilitation
Physical Stimulation - instrumentation
Pipette aspiration
Silicones
Tissues, organs and organisms biophysics
Vibration
Viscoelasticity
Vocal Cords - physiology
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Summary:Abstract A measurement setup combined with a Finite Element (FE) simulation is presented to determine the elasticity modulus of soft materials as a function of frequency. The longterm goal of this work is to measure in vitro the elasticity modulus of human vocal folds over a frequency range that coincides with the range of human phonation. The results will assist numerical simulations modeling the phonation process by providing correct material parameters. Furthermore, the measurements are locally applied, enabling to determine spatial differences along the surface of the material. In this work the method will be presented and validated by applying it to silicones with similar characteristics as human vocal folds. Three silicone samples with different consistency were tested over a frequency range of 20–250 Hz. The results of the pipette aspiration method revealed a strong frequency dependency of the elasticity modulus, especially below 100 Hz. In this frequency range the elasticity moduli of the samples varied between 5 and 27 kPa.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2010.01.035