Estrogen receptor status and response to chemotherapy in advanced breast cancer: The tufts‐shattuck‐pondville experience

Eighty‐eight patients with advanced breast cancer were retrospectively reviewed to compare estrogen receptor (ER) data with response to cytotoxic chemotherapy. All assays were done in a single laboratory. All patients were cared for at a single institution. Thirty‐four patients were treated with che...

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Bibliographic Details
Published in:Cancer 1980-12, Vol.46 (S12), p.2919-2921
Main Authors: Rosenbaum, Charles, Marsland, Thomas A., Stolbach, Leo L., Raam, Shanthi, Cohen, Joseph L.
Format: Article
Language:English
Subjects:
Age Factors
Antineoplastic Agents - therapeutic use
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Drug Therapy, Combination
Female
Humans
Prednisone - therapeutic use
Prognosis
Receptors, Estrogen - metabolism
Retrospective Studies
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Summary:Eighty‐eight patients with advanced breast cancer were retrospectively reviewed to compare estrogen receptor (ER) data with response to cytotoxic chemotherapy. All assays were done in a single laboratory. All patients were cared for at a single institution. Thirty‐four patients were treated with chemotherapy, 30 of whom were evaluable for response by criteria of the Eastern Cooperative Oncology Group (ECOG). Of 16 ER‐positive patients, 12 (75%) responded; of 14 ER‐negative patients, six (43%) responded (P < 0.05). The two groups did not differ significantly in chemotherapy received, menopausal status, site of predominant disease, stage at diagnosis, or disease‐free interval. Response to cytotoxic chemotherapy does not appear to correlate with ER status.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19801215)46:12+<2919::AID-CNCR2820461434>3.0.CO;2-X