Preparation, characterization, and stability of new prostaglandin E2 gel for local administration

A new gel delivery system for the local application of prostaglandin E2 consists of drug incorporated in the matrix of a cross-linked starch polymer. The properties of the starch powder provide a stabilizing milieu for the labile prostaglandin E2 and, by addition of saline, a ready-to-use gel for im...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1980-11, Vol.69 (11), p.1271-1273
Main Authors: Harris, A.S., Kirstein-Pedersen, A., Stenberg, P., Ulmsten, U., Wingerup, L.
Format: Article
Language:English
Subjects:
Administration, Topical
and stability
and stability of gel delivery system
characterization
Drug Contamination
Drug delivery systems-prostaglandin E2 gel
Drug delivery systems—prostaglandin E2 gel, preparation, characterization, and stability
Drug Stability
Gels
preparation
Prostaglandin E2-preparation
Prostaglandin E2—preparation, characterization, and stability of gel delivery system
Prostaglandins E - administration & dosage
Prostaglandins E - standards
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Summary:A new gel delivery system for the local application of prostaglandin E2 consists of drug incorporated in the matrix of a cross-linked starch polymer. The properties of the starch powder provide a stabilizing milieu for the labile prostaglandin E2 and, by addition of saline, a ready-to-use gel for immediate local administration. The gel offers advantages over existing preparations in terms of chemical and microbiological stability, homogeneity, and dosage safety. This report outlines the pharmaceutical aspects involved in the development of the delivery system.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600691110