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Autowave distribution of nitric oxide and its endogenous derivatives in biosystems strongly enhances their biological effects: A working hypothesis
It is hypothesized that in cells producing nitric oxide (NO), NO and its endogenous derivatives (low-molecular S-nitrosothiols and dinitrosyl iron complexes (DNIC) with thiol-containing ligands) can move in the intracellular space not only by diffusion but also in an autowave mode. This hypothesis i...
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Published in: | Nitric oxide 2010-11, Vol.23 (3), p.175-180 |
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creator | Vanin, Anatoly F. Mikoyan, Vasak D. Rubtsov, Nikolai M. Kubrina, Lioudmila N. |
description | It is hypothesized that in cells producing nitric oxide (NO), NO and its endogenous derivatives (low-molecular
S-nitrosothiols and dinitrosyl iron complexes (DNIC) with thiol-containing ligands) can move in the intracellular space not only by diffusion but also in an autowave mode. This hypothesis is based on the previously obtained data on autowave distribution of DNIC with glutathione following application of a drop of a solution of Fe
2+
+
glutathione onto the surface of a thin layer of a
S-nitrosoglutathione solution. The appearance of autowaves is conditioned by a self-regulating self-sustained system arising in the process. This system consists of self-convertible DNIC and
S-nitrosothiols as well as free ferrous iron ions, thiols and NO and can function in the autowave regime for several seconds with subsequent passage to a steady state maintained by chemical equilibrium between DNIC and their constituent components (free Fe
2+ ions, thiols,
S-nitrosothiols and NO). Possible advantages of autowave distribution of NO and its endogenous derivatives in the intracellular space over free diffusion, which might entail higher efficiency of their biological action, are discussed. |
doi_str_mv | 10.1016/j.niox.2010.07.002 |
format | article |
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S-nitrosothiols and dinitrosyl iron complexes (DNIC) with thiol-containing ligands) can move in the intracellular space not only by diffusion but also in an autowave mode. This hypothesis is based on the previously obtained data on autowave distribution of DNIC with glutathione following application of a drop of a solution of Fe
2+
+
glutathione onto the surface of a thin layer of a
S-nitrosoglutathione solution. The appearance of autowaves is conditioned by a self-regulating self-sustained system arising in the process. This system consists of self-convertible DNIC and
S-nitrosothiols as well as free ferrous iron ions, thiols and NO and can function in the autowave regime for several seconds with subsequent passage to a steady state maintained by chemical equilibrium between DNIC and their constituent components (free Fe
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S-nitrosothiols and dinitrosyl iron complexes (DNIC) with thiol-containing ligands) can move in the intracellular space not only by diffusion but also in an autowave mode. This hypothesis is based on the previously obtained data on autowave distribution of DNIC with glutathione following application of a drop of a solution of Fe
2+
+
glutathione onto the surface of a thin layer of a
S-nitrosoglutathione solution. The appearance of autowaves is conditioned by a self-regulating self-sustained system arising in the process. This system consists of self-convertible DNIC and
S-nitrosothiols as well as free ferrous iron ions, thiols and NO and can function in the autowave regime for several seconds with subsequent passage to a steady state maintained by chemical equilibrium between DNIC and their constituent components (free Fe
2+ ions, thiols,
S-nitrosothiols and NO). Possible advantages of autowave distribution of NO and its endogenous derivatives in the intracellular space over free diffusion, which might entail higher efficiency of their biological action, are discussed.</description><subject>Autowaves</subject><subject>Dinitrosyl iron complexes</subject><subject>Glutathione - metabolism</subject><subject>Iron - metabolism</subject><subject>Models, Biological</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitrogen Oxides - metabolism</subject><subject>S-nitrosothiols</subject><subject>S-Nitrosothiols - metabolism</subject><subject>Sulfhydryl Compounds - metabolism</subject><issn>1089-8603</issn><issn>1089-8611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuEzEQhlcIREvLC3BAvnFKGK839i7iElVtQarUCz1bXns2mbCxg-1Nm-fghXGU0mNP4_F880vz_1X1icOcA5dfN3NP4WleQ_kANQeo31TnHNpu1krO3768QZxVH1LaAEAjWvm-OqtBCiE7fl79XU45PJo9MkcpR-qnTMGzMDBPpbUsPJFDZrxjlBND78IKfZgScxhpbzLtMTHyrKeQDinjNrGiE_xqPBR6bbwt87xGikdkDCuyZmQ4DGhz-saW7DHE3-RXbH3YhcIlSpfVu8GMCT8-14vq4eb619WP2d397c-r5d3MisUiz_paCcWbQWItVevabkDhuOzrlvc1iEE1nWihgUE0ZcgdmEYCdMBNcWdhrLiovpx0dzH8mTBlvaVkcRyNx3KhVgvRdQ0oVcj6RNoYUoo46F2krYkHzUEfs9AbfcxCH7PQoHTJoix9fpaf-i26l5X_5hfg-wnAcuSeMOpkCYthjmJxR7tAr-n_A09Snes</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Vanin, Anatoly F.</creator><creator>Mikoyan, Vasak D.</creator><creator>Rubtsov, Nikolai M.</creator><creator>Kubrina, Lioudmila N.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Autowave distribution of nitric oxide and its endogenous derivatives in biosystems strongly enhances their biological effects: A working hypothesis</title><author>Vanin, Anatoly F. ; Mikoyan, Vasak D. ; Rubtsov, Nikolai M. ; Kubrina, Lioudmila N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-b273714f6e2678d89fe3d16b281b203f74938040f34d891d0a4600901a6115ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Autowaves</topic><topic>Dinitrosyl iron complexes</topic><topic>Glutathione - metabolism</topic><topic>Iron - metabolism</topic><topic>Models, Biological</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitrogen Oxides - metabolism</topic><topic>S-nitrosothiols</topic><topic>S-Nitrosothiols - metabolism</topic><topic>Sulfhydryl Compounds - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanin, Anatoly F.</creatorcontrib><creatorcontrib>Mikoyan, Vasak D.</creatorcontrib><creatorcontrib>Rubtsov, Nikolai M.</creatorcontrib><creatorcontrib>Kubrina, Lioudmila N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nitric oxide</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanin, Anatoly F.</au><au>Mikoyan, Vasak D.</au><au>Rubtsov, Nikolai M.</au><au>Kubrina, Lioudmila N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autowave distribution of nitric oxide and its endogenous derivatives in biosystems strongly enhances their biological effects: A working hypothesis</atitle><jtitle>Nitric oxide</jtitle><addtitle>Nitric Oxide</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>23</volume><issue>3</issue><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>1089-8603</issn><eissn>1089-8611</eissn><abstract>It is hypothesized that in cells producing nitric oxide (NO), NO and its endogenous derivatives (low-molecular
S-nitrosothiols and dinitrosyl iron complexes (DNIC) with thiol-containing ligands) can move in the intracellular space not only by diffusion but also in an autowave mode. This hypothesis is based on the previously obtained data on autowave distribution of DNIC with glutathione following application of a drop of a solution of Fe
2+
+
glutathione onto the surface of a thin layer of a
S-nitrosoglutathione solution. The appearance of autowaves is conditioned by a self-regulating self-sustained system arising in the process. This system consists of self-convertible DNIC and
S-nitrosothiols as well as free ferrous iron ions, thiols and NO and can function in the autowave regime for several seconds with subsequent passage to a steady state maintained by chemical equilibrium between DNIC and their constituent components (free Fe
2+ ions, thiols,
S-nitrosothiols and NO). Possible advantages of autowave distribution of NO and its endogenous derivatives in the intracellular space over free diffusion, which might entail higher efficiency of their biological action, are discussed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20633691</pmid><doi>10.1016/j.niox.2010.07.002</doi><tpages>6</tpages></addata></record> |
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subjects | Autowaves Dinitrosyl iron complexes Glutathione - metabolism Iron - metabolism Models, Biological Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - metabolism Nitrogen Oxides - metabolism S-nitrosothiols S-Nitrosothiols - metabolism Sulfhydryl Compounds - metabolism |
title | Autowave distribution of nitric oxide and its endogenous derivatives in biosystems strongly enhances their biological effects: A working hypothesis |
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