Resurrection men and the FEF25-75

The hope was that it was now possible to think of the early detection of a progressive illness like chronic obstructive pulmonary disease at a time when interventions would be most likely to change its natural history. Because all of the regions of the lung fill and empty synchronously,6 and because...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2010-09, Vol.126 (3), p.535-536
Main Author: McFadden, E.R., MD
Format: Article
Language:English
Subjects:
Airway management
Airway Obstruction - diagnosis
Allergy and Immunology
Asthma
Asthma - diagnosis
Asthma - physiopathology
asthma management
Child
FEF25-75
Female
Humans
Male
Maximal Midexpiratory Flow Rate
peripheral airway obstruction
resurrection men
Studies
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Summary:The hope was that it was now possible to think of the early detection of a progressive illness like chronic obstructive pulmonary disease at a time when interventions would be most likely to change its natural history. Because all of the regions of the lung fill and empty synchronously,6 and because nonuniform distribution of disease in the periphery disrupts this pattern, the diagnostic tack usually taken was to use tests sensitive to respiratory rate such as frequency dependent compliance or resistance.7 Later, other tests were explored like the distribution of alveolar air, increases in alveolar-arterial gradients for oxygen, and dynamic hyperinflation.8 The common denominator underlying all of them was that if the lung units filled and emptied asynchronously, such tests would be abnormal, and the discrepancies would worsen as respiratory frequency rose. [...]there were no epidemiologic data to show whether, or how, the FEF25-75 measured or predicted disease activity over time.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.06.035