Pityriasis rosea and herpesviruses: Facts and controversies

Abstract Pityriasis rosea is an acute exanthem with many clinical and epidemiologic features of an infectious disease. To date, human herpesvirus (HHV)-6 and HHV-7 appear to be the most indicted culprits, and the evidence in favor of this hypothesis and the controversial results produced elsewhere a...

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Bibliographic Details
Published in:Clinics in dermatology 2010-09, Vol.28 (5), p.497-501
Main Authors: Rebora, Alfredo, MD, Drago, Francesco, MD, Broccolo, Francesco, MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dermatology
Female
Herpesvirus 6, Human - genetics
Herpesvirus 6, Human - isolation & purification
Herpesvirus 7, Human - genetics
Herpesvirus 7, Human - isolation & purification
Herpesvirus 8, Human - genetics
Herpesvirus 8, Human - isolation & purification
Humans
Male
Medical sciences
Pityriasis Rosea - epidemiology
Pityriasis Rosea - immunology
Pityriasis Rosea - virology
Polymerase Chain Reaction
Roseolovirus Infections - complications
Skin involvement in other diseases. Miscellaneous. General aspects
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Summary:Abstract Pityriasis rosea is an acute exanthem with many clinical and epidemiologic features of an infectious disease. To date, human herpesvirus (HHV)-6 and HHV-7 appear to be the most indicted culprits, and the evidence in favor of this hypothesis and the controversial results produced elsewhere are discussed. The complex pathophysiology of HHV-6 and HHV-7 infection, their diffusion in the population at large, the difficulties of understanding whether the infection is still latent or is clinically manifest, and well as whether pityriasis rosea depends on a reinfection or on a viral reactivation, all make the issue extremely difficult to study and understand.
ISSN:0738-081X
1879-1131
DOI:10.1016/j.clindermatol.2010.03.005