Genome-wide association study of childhood acute lymphoblastic leukemia in Korea

• Published in: Leukemia research 2010-10, Vol.34 (10), p.1271-1274
• Main Authors: Han, Sohee, Lee, Kyoung-Mu, Park, Sue K, Lee, Jong Eun, Ahn, Hyo Seop, Shin, Hee Young, Kang, Hyoung Jin, Koo, Hong Hoe, Seo, Jong Jin, Choi, Ji Eun, Ahn, Yoon-Ok, Kang, Daehee
• Format: Article
• Language: English
• Subjects: Adolescent; Case-Control Studies; CCAAT-Enhancer-Binding Proteins - genetics; Child; Child, Preschool; Childhood acute lymphoblastic leukemia (ALL); DNA-Binding Proteins - genetics; Female; Genome-Wide Association Study; Genome-wide association study (GWAS); Hematology, Oncology and Palliative Medicine; Humans; Ikaros Transcription Factor - genetics; Infant; Infant, Newborn; Korea; Male; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Single nucleotide polymorphism (SNP); Transcription Factors - genetics
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/j.leukres.2010.02.001

Abstract We conducted a genome-wide association study of childhood acute lymphoblastic leukemia (ALL) in a case–control study conducted in Korea. Incident childhood ALL cases ( n = 50) and non-cancer controls ( n = 50) frequency-matched to cases by age and sex, recruited from three teaching hospitals in Seoul between 2003 and 2008, were genotyped using Affymetrix SNP Array 6.0 platform. ALL risks were estimated as odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age and birth weight. The false discovery rate (FDR) was used for adjusting multiple tests. Of these 1 million SNPs, six SNPs in 4 genes ( HAO 1 rs6140264, EPB 41 L 2 rs9388856, rs9388857, rs1360756, C 2 orf 3 12105972, MAN 2 A 1 rs3776932) were strongly associated with childhood ALL risk ( Pdominant ≤ 0.0001 and Ptrend < 0.006). These SNPs remained significant after FDR adjustment (FDR value