Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients

Abstract The role of the Smac/DIABLO protein, a novel apoptosis agonist, in acute myeloid leukemia (AML) is not clearly determined. The expression of Smac/DIABLO protein in AML leukemic cells and its relationship with clinical outcome was evaluated in this study. The intracellular expression of Smac...

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Bibliographic Details
Published in:Leukemia research 2010-10, Vol.34 (10), p.1308-1313
Main Authors: Pluta, Agnieszka, Wrzesien-Kus, Agata, Cebula-Obrzut, Barbara, Wolska, Anna, Szmigielska-Kaplon, Anna, Czemerska, Magdalena, Pluta, Piotr, Robak, Tadeusz, Smolewski, Piotr, Wierzbowska, Agnieszka
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Adult
Aged
Aged, 80 and over
Apoptosis
Female
Flow Cytometry
Hematology, Oncology and Palliative Medicine
Humans
Intracellular Signaling Peptides and Proteins - analysis
Intracellular Signaling Peptides and Proteins - genetics
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - mortality
Male
Middle Aged
Mitochondrial Proteins - analysis
Mitochondrial Proteins - genetics
Prognosis
Risk Factors
Smac/DIABLO
Treatment Outcome
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Summary:Abstract The role of the Smac/DIABLO protein, a novel apoptosis agonist, in acute myeloid leukemia (AML) is not clearly determined. The expression of Smac/DIABLO protein in AML leukemic cells and its relationship with clinical outcome was evaluated in this study. The intracellular expression of Smac/DIABLO protein was assessed using multi-color flow cytometry in 71 newly diagnosed AML patients treated with conventional chemotherapy. It was found that the high expression of Smac/DIABLO protein was an independent prognostic factor in terms of higher complete remission rate ( p < 0.001) and longer overall survival ( p = 0.003). Moreover the low expression of Smac/DIABLO protein was associated with poor karyotype.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2009.11.030