Responsive and mitochondria-specific ruthenium(II) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

A mitochondria-permeable ruthenium(II) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (Phi(Delta) = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2010-09, Vol.46 (36), p.6678-6680
Main Authors: Ke, Hanzhong, Wang, Hongda, Wong, Wai-Kwok, Mak, Nai-Ki, Kwong, Daniel W J, Wong, Ka-Leung, Tam, Hoi-Lam
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Coordination Complexes - chemistry
Coordination Complexes - toxicity
Humans
Infrared Rays
Mitochondria - drug effects
Photons
Photosensitizing Agents - chemistry
Photosensitizing Agents - toxicity
Ruthenium - chemistry
Singlet Oxygen - metabolism
Singlet Oxygen - toxicity
Ultraviolet Rays
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Description
Summary:A mitochondria-permeable ruthenium(II) complex has been designed as a responsive probe which may be used to sensitize the formation of singlet oxygen (Phi(Delta) = 0.93) and cause local damage in cellulo when exposed to UV and near-infrared laser excitation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc01848a