Factors Associated With Changes in Coagulation Profiles After Living Donor Hepatectomy

• Published in: Transplantation proceedings 2010-09, Vol.42 (7), p.2430-2435
• Main Authors: Kim, Y.K, Shin, W.J, Song, J.G, Jun, I.G, Kim, H.Y, Seong, S.H, Sang, B.H, Hwang, G.S
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Blood Coagulation - physiology; Blood Coagulation Disorders - etiology; Blood Pressure; Cholecystectomy; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Hepatectomy - methods; Humans; International Normalized Ratio; Liver, biliary tract, pancreas, portal circulation, spleen; Living Donors; Male; Medical sciences; Middle Aged; Partial Thromboplastin Time; Postoperative Complications - blood; Retrospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Tissue, organ and graft immunology
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.04.069

Abstract Background Hepatic resection may be associated with postoperative coagulopathy. However, there is limited information about the predictors affecting coagulopathy after donor hepatectomy. We evaluated the contributors of maximal changes in prothrombin time (PT), activated thromboplastin time (aPTT), and platelet count in the development of postoperative coagulopathy. Methods We retrospectively analyzed 864 living donors, all of whom received general anesthesia using desflurane, isoflurane, or sevoflurane. A coagulation derangement was defined as one or more of the following events postoperatively: peak PT >1.5 international normalized ratio (INR; highest quartile of PT), peak aPTT >46 seconds (highest quartile of aPTT), or nadir platelet count