Prospective investigation of serum anti-Müllerian hormone concentration in ovulatory intrauterine insemination patients: a preliminary study

Abstract This preliminary prospective study investigated serum anti-Müllerian hormone (AMH) through correlations to other basal parameters (123 patients) and according to ovarian response to 75 IU recombinant follicle-stimulating hormone (rFSH)/day (62 patients) in ovulatory patients’ first rFSH tre...

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Bibliographic Details
Published in:Reproductive biomedicine online 2010-05, Vol.20 (5), p.582-587
Main Authors: Freiesleben, N la Cour, Rosendahl, M, Johannsen, TH, Løssl, K, Loft, A, Bangsbøll, S, Friis-Hansen, L, Pinborg, A, Andersen, A Nyboe
Format: Article
Language:English
Subjects:
Adult
Anti-Mullerian Hormone - blood
anti-Müllerian hormone
Dose-Response Relationship, Drug
Female
Follicle Stimulating Hormone - administration & dosage
Humans
Insemination, Artificial
IUI
mild FSH stimulation
Müllerian-inhibiting substance
Obstetrics and Gynecology
ovarian response
ovarian stimulation
Ovulation
Pregnancy
Prospective Studies
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Summary:Abstract This preliminary prospective study investigated serum anti-Müllerian hormone (AMH) through correlations to other basal parameters (123 patients) and according to ovarian response to 75 IU recombinant follicle-stimulating hormone (rFSH)/day (62 patients) in ovulatory patients’ first rFSH treatment cycle before intrauterine insemination. Mean age of the patients was 33 years. Serum AMH significantly correlated to age ( r = −0.38), antral follicle count (AFC) ( r = 0.68), ovarian volume ( r = 0.40), FSH ( r = −0.31), ( P < 0.001) and cycle length ( r = 0.26, P = 0.004). Serum AMH median (interquartile range; IQR) was 8.5 pmol/l (1.9–15.1) in hyporesponders (one mature follicle) versus 10.7 (7.3–17.3) in normal responders (2–3 follicles, with a maximum of two follicles ⩾18 mm and no need for dose reduction) and 13.4 (4.4–24.2) in hyperresponders (>2–3 mature follicles or dose reduction). There was a significant trend over response groups for body weight ( P = 0.005), body mass index ( P = 0.035), AFC ( P = 0.031) and FSH ( P = 0.001). Serum AMH median (IQR) was 10.6 pmol/l (6.9–18.2) in the 23 patients who achieved an ongoing pregnancy versus 10.5 (5.9–17.2) in the 100 non-pregnant women. Serum AMH may not be the best marker of the ovarian response in these patients.
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2010.02.007