Regulation of membrane biogenesis in autophagy via PI3P dynamics

In autophagy, cytoplasmic substrates are targeted for degradation in the lysosome via membrane structures called autophagosomes. The formation of the autophagosome is the primary regulatory point for autophagy activity, and PI3P plays a central role in this process. In this review, we will discuss t...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2010-09, Vol.21 (7), p.671-676
Main Authors: Noda, Takeshi, Matsunaga, Kohichi, Taguchi-Atarashi, Naoko, Yoshimori, Tamotsu
Format: Article
Language:English
Subjects:
Animals
Autophagosome
Autophagy
Humans
Intracellular Membranes - metabolism
Phagosomes - metabolism
Phosphatidylinositol 3-Kinases - metabolism
Phosphatidylinositol Phosphates - metabolism
Phosphoric Monoester Hydrolases - metabolism
PI3-kinase
PI3-phosphatase
PI3P
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Summary:In autophagy, cytoplasmic substrates are targeted for degradation in the lysosome via membrane structures called autophagosomes. The formation of the autophagosome is the primary regulatory point for autophagy activity, and PI3P plays a central role in this process. In this review, we will discuss the role of PI3P in autophagosome formation from three different perspectives: PI3-kinase, PI3-binding proteins, and PI3-phosphatase. Recent developments in this field suggest that the local PI3P concentration is dynamically regulated during autophagy, and that this molecule is critical to the proper control of autophagy.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2010.04.002